Age-Related Macular Degeneration by Jennifer I. Lim

By Jennifer I. Lim

This reference showcases exudative and nonexudative AMD therapy concepts utilizing argon and diode lasers, submacular and macular translocation surgical procedure, photodynamic remedy, radiation, feeder vessel therapy, thermotherapy, and antiangiogenesis medications. together with a hundred and sixty colour illustrations, Age-Related Macular Degeneration will gain scientific ophthalmologists, pathologists, physiologists, and pharmacologists; optometrists; phone and molecular biologists and biochemists; retinal experts; AMD researchers; and graduate and clinical university scholars in those disciplines.

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Verdugo ME, Ray J. Age-related increase in activity of specific lysosomal enzymes in the human retinal pigment epithelium. Exp Eye Res 1997;65:231–240. 66. Loeffler KU, Mangini NJ. Immunolocalization of ubiquitin and related enzymes in human retina and retinal pigment epithelium. Graefes Arch Clin Exp Ophthalmol 1997;235:248–254. 67. Miyamoto L, Fitzpatrick TB. On the nature of the pigment in retinal pigment epithelium. Science 1957;126:449–450. 68. Ts’o MO and Friedman E. The retinal pigment epithelium.

Alternatively, via scavenging and phagocytosis (step 3), macrophages can become “reparative” resulting in local tissue rearrangement. become partially activated into reparative macrophages by growth factors and debris released by oxidant-injured RPE (65). 2. 1–1% of blood mononuclear cells (66). However, in tissue sites, DC become large (15–30 µm) with cytoplasmic veils that form extensions 2–3 times the diameter of the cell, resembling the dendritic structure of neurons. In many nonlymphoid and lymphoid organs, dendritic cells become a system of antigen-presenting cells.

Aging of Retina and RPE 13 63. Shelton DN, Chang E, Whittier PS, Choi D, Funk WD. Microarray analysis of replicative senescence. Curr Biol 1999;9:939–945. 64. Marmor MF. Structure, function, and disease of the retinal pigment epithelium. In: Marmor MF, Wolfensberger TJ, eds. The Retinal Pigment Epithelium: Function and Disease, 2nd ed. Oxford: Oxford University Press, 1998:3–12. 65. Verdugo ME, Ray J. Age-related increase in activity of specific lysosomal enzymes in the human retinal pigment epithelium.

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