Antibodies for infectious diseases by James E., Jr. Crowe, Diana Boraschi, Rino Rappuoli

By James E., Jr. Crowe, Diana Boraschi, Rino Rappuoli

State-of-the-art experiences overlaying significant facets of antibodies and intervention opposed to infectious diseases

The connection among antibodies and infectious ailments has spawned complete similar fields of analysis. Antibodies for Infectious Diseases offers views from major learn scientists and summarizes the fantastic growth during this sector right into a unmarried definitive resource.

Providing a wide survey of crucial facets of the sphere of antibodies for infectious ailments, this book

  • presents common gains relating constitution, functionality, isotype, and the function of supplement in antibody function
  • examines the function of antibodies in antimicrobial immunity with particular targets
  • details new equipment for expression of monoclonal antibodies, in crops or by means of move of antibody genes for in vivo expression in handled subjects

Antibodies for Infectious Diseases is a accomplished reference for researchers, pharmaceutical builders, and future health care execs at the prestige of the improvement of antibody-based treatments for treating infectious illnesses. it's also priceless as supplemental examining for higher point existence sciences scholars.

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In comparison, $63 for an 8-week treatment with fluorouracil, which was the standard treatment until the mid-1990s, puts the cost of antibody treatments in perspective. Highly specific antibodies monoclonal antibodies (each produced by culture of cells all derived from the same single cell), can be selected for and generated from immunized humans or animals in several different ways: (i) phage display of a human variable light segment library from several donors and B cells, followed by cycles of panning against target antigen, selection of phages with the desired target specificity, and subsequent cloning and expression in a cell line for expression; (ii) the use of transgenic mice carrying the genes for human IgG and immortalization of the mouse B cells by fusing them with myeloma cells (the hybridoma technology); and (iii) isolation of memory B cells or activated memory B cells (plasmablasts) from patients that have been or are exposed to the infectious agent.

GENERAL FEATURES OF IMMUNOGLOBULINS Functions of Antibodies DONALD N. FORTHAL1 2 INTRODUCTION In the setting of infectious diseases, antibody function refers to the biological effect that an antibody has on a pathogen or its toxin. Thus, assays that measure antibody function are differentiated from those that strictly measure the ability of an antibody to bind to its cognate antigen. Examples of antibody functions include neutralization of infectivity, phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and complement-mediated lysis of pathogens or of infected cells.

Stewart R, Thom G, Levens M, Güler-Gane G, Holgate R, Rudd PM, Webster C, Jermutus L, Lund J. 2011. A variant human IgG1-Fc mediates improved ADCC. Protein Eng Des Sel 24:671–678. Niwa R, Hatanaka S, Shoji-Hosaka E, Sakurada M, Kobayashi Y, Uehara A, Yokoi H, Nakamura K, Shitara K. 2004. Enhancement of the antibody-dependent cellular cytotoxicity of low-fucose IgG1 is independent of Fc-q gammaRIIIa functional polymorphism. Clin Cancer Res 10:6248–6255. Hezareh M, Hessell AJ, Jensen RC, van de Winkel JGJ, Parren PWHI.

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