Antimicrobial Peptides and Human Disease (Current Topics in by William Shafer

By William Shafer

Microbes are in our midst quickly after start. fortunately, the variety of risk free (and usually helpful) microbes some distance outnumber those who may do us damage. Our skill to ward-off pathogens in our surroundings, together with those who can colonize our external and/or inside surfaces, is determined by the integrative motion of the innate and adaptive immunity structures. This quantity of CTMI, entitled Antimicrobial Peptides and Human disorder, is devoted to the position of antimicrobial peptides (AMPs) within the innate host security method of homo sapiens.

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Additional resources for Antimicrobial Peptides and Human Disease (Current Topics in Microbiology and Immunology)

Sample text

Mast Cells . . . . . . . . . . . . . . . . . . . . . . . Epithelial Cells . . . . . . . . . . . . . . . . . . . . . 2 Host Defence Peptides in the Adaptive Immune Response . . . . . . 46 Adjuvant Activity . . . . . . . . . . . . . . . . . . . . 46 Mechanisms . . . . . . . . . . . . . . . . . . . . . . 50 4 Conclusion . . . . . . . . . . . . . . . . . . . . . . 53 References . .

2002b; Hase et al. 2003; Murakami et al. 2005). Generally epithelial cells have been shown to produce the hCAP-18 form. Although the hCAP-18 has been shown to be cleaved by the neutrophil protease, protease 3, when released from neutrophils, it is not entirely clear how or when hCAP18 is cleaved when it is produced by epithelial cells. There are a variety of processed forms of hCAP-18 that result from as-yet uncharacterised cleavage processes. For example, a 6-kDa form is found in gastric juice (Hase et al.

This increase in expression at both the RNA and protein levels was clearly evident at the migrating front of the wound during re-epithelialisation. Levels of hCAP-18 decreased following wound closure and eventually returned to baseline levels when the wound was intact and reepithelisation was complete. hCAP-18 was found to be an active component in the process of re-epithelisation since antibodies specific for the peptide decreased the rate of re-epithelisation in a concentration-dependent manner (Heilborn et al.

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