Antiphospholipid Syndrome in Systemic Autoimmune Diseases by Ricard Cervera, Gerard Espinosa, Munther Khamashta MD FRCP

By Ricard Cervera, Gerard Espinosa, Munther Khamashta MD FRCP PhD

Antiphospholipid syndrome is an autoimmune disorder that explanations irregular blood clots. it really is now well-known as a big explanation for universal stipulations, together with stroke, middle assault, miscarriage, epilepsy and reminiscence loss and as such is gaining acceptance in all branches of medication, from obstetrics to cardiology, from psychiatry to orthopedics.

This ebook presents an summary of our present knowing of this significant disorder. It contains the most recent info at the new pathogenetic mechanisms concerned in addition to scientific manifestations in either ''the thrombotic” and ''non-thrombotic” manifestations of this crucial disorder.

* entire evaluate of this significant disease
* contains details on therapies to be had

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Extra info for Antiphospholipid Syndrome in Systemic Autoimmune Diseases

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Similar to other viral diseases such as hepatitis C and HIV, no association with features of APS was noted with CMV and the presence of aPL (Amin, 2008). Finally, aPL have been detected in patients with other viral infections as 27 well, including varicella virus, human T-lymphotropic virus type 1, and Epstein–Barr virus (Amin, 2008). aPL have also been seen in various bacterial infections. However, increases in aPL are usually b2GPI-independent and not typically associated with thrombotic events (Amin, 2008).

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313, 152–156. , Schwartzman, S. 2000. Validation of the Sapporo criteria for antiphospholipid syndrome. Arthritis Rheum. 43, 440–443. A. 1990. Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Ann. Intern. Med. 112, 682–698. F. 1999. Association of antibodies to beta-2glycoprotein I with pregnancy loss and pregnancy-induced hypertension: a prospective study in low-risk pregnancy. Obstet. Gynecol. 93, 193–198.

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